Syn-Ake Peptide Serum Booster

Ultra-Smoothing for Vertical Lines, including the 11's! You know the vertical lines between the eyebrows that make you look like you are frowning.

Syn®-Ake is an anti-aging peptide that smooths and tightens the skin, targets the forehead, vertical marionette lines, and firming facial features.

$49.99
OR
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Syn-Ake is used at 1 to 5% for the look of smoothed lines — particularly the vertical ones. It is the peptide formulators reach for when the concern is lip lines, the 11s between the brows, or forehead creases.

This is a formulation ingredient, not a finished serum. Do not apply it undiluted.

What is in the bottle

INCI: Water (Aqua), Dipeptide Diaminobutyroyl Benzylamide Diacetate

Clear liquid. Water-soluble. Vegan. Molecular weight under 500 Daltons, which is small as cosmetic peptides go.

No preservative. Add one to your finished blend — Leucidal Liquid or Leucidal Complete at 2–4% — and keep it refrigerated.

How much to add

Recommended usage rate is 1 to 5%. Using our house rate of 9 drops per 1% per fluid ounce:

Concentration Into 1 oz Into 2 oz
1% 9 drops · 0.3 g 18 drops · 0.6 g
3% 27 drops · 0.9 g 54 drops · 1.8 g
5% 45 drops · 1.5 g 90 drops · 3.0 g

Full conversions on the serum booster chart.

What it is for

Syn-Ake is the vertical-line peptide. Where Argireline is usually reached for on the forehead and crow's feet, Syn-Ake is the one for:

  • Lip lines and the vertical creases above the mouth
  • The 11s between the brows
  • Forehead lines
  • Laugh lines around the mouth

It also contributes to the look of a smoother, firmer surface generally, which is why it turns up in tightening formulas as well as line-focused ones.

How to use it

  1. Choose a water-based cream, serum or gel as your base.
  2. Add the drops for 1 to 5%.
  3. Add a preservative at 2–4% — this booster has none.
  4. Cap and shake, or stir it through a cream.
  5. Refrigerate what you are not using.

Give it time. Syn-Ake is cumulative — most people work with it for about a month before judging what it is doing.

If you have sensitive skin, patch test on the inside of the arm first, as with any new active.

What to pair it with

Syn-Ake layers with Argireline, Snap-8 and Inyline. All four work on the look of lines through different routes, so combining them is not doubling up on the same thing.

A common blend: Syn-Ake for the vertical lines, Argireline across the forehead, in a hyaluronic acid base.

Why buy it raw

Finished products naming Syn-Ake rarely disclose the concentration, and a 0.5 oz bottle of the booster blends several ounces of serum. Blend it yourself and the number is yours — because you counted it in.

New to this? Start with the bulk bases and the DIY formulas.

Storage

Refrigerate on arrival. The blue glass keeps light out. Store the finished blend cold too.

For external use only. Cosmetic grade. Do not apply undiluted to skin. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Syn-Ake is a registered trademark of DSM.

EWG Score

The Skin Deep® ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. Learn how EWG Skin Deep scores work →
1-2 Low Hazard
3-6 Moderate Hazard
7-10 High Hazard

  • Glycerin Origin:
  • Water Origin:
  • Dipeptide Diaminobutyroyl Benzylamide Diacetate Origin:

How does Syn-Ake work?
Syn-Ake is a tripeptide that combines three amino acids in a sequence. It is based on a naturally occurring phenomenon that blocks neuromuscular movements and relaxes the facial muscles that cause expression lines.
Does this product need to be refrigerated?
We recommend placing Syn-Ake in your fridge to keep it fresh for the next time you need it.

INCI: Glycerin (and) Water (and) Dipeptide Diaminobutyroyl Benzylamide Diacetate

Recommended Usage Rate: 1-5%

Place in the refrigerator upon arrival.

Color: Colorless

Appearance: Clear liquid

Solubility: Water-soluble

pH: 4.5-5.5

Scent: Slight, natural scent

Storage: Store in a cool, dry place

Shelf-life: 12 months after opening

Country of Origin: France

Raw Material: Plant-based

Animal Testing: Cruelty-free

GMO: Non-GMO

Vegan: Yes

CAS: 56-81-5

HS Code: 3504.00

Dipeptide Diaminobutyroyl Benzylamide Diacetate is a wrinkle-smoothing peptide that inhibits muscle contractions.

Add 45 drops to a 1-ounce skincare product, bulk base, or formula for a 5% concentration of Syn-Ake.

Add 18 drops of Syn-Ake to a 2-ounce skincare product, bulk base, or formula for a 1% concentration.

Syn-Ake is an anti-wrinkle cosmetic active used for formulating and is not intended for direct skin use. However, if you have sensitive skin, perform a patch test with this and all other ingredients.

Add enough drops of Syn-Ake to your favorite anti-aging cream or skincare product to achieve a 1-5% concentration. You can also use your own recipe. This will be enough to firm and tone your skin, significantly diminishing smile and frown lines as you continue using it.

Once you've added the peptide to your product, shake or stir. Then, put the cap back on the serum booster bottle and store it in the refrigerator. You do not need to refrigerate your finished formula. In just a few days, you will start seeing results.

Syn-ake also has a cumulative face-firming effect. Therefore, you should use it for at least 30 days until you see full firming results.

The bottle's blue tint will protect this potent peptide from breaking down due to light exposure, and the chilled environment of the refrigerator will keep it from losing strength.

When you need to use it next, it will be just as fresh and active as when you first opened it.

Syn-Ake is widely utilized in the skincare and cosmetics industry to enhance smoothing and skin-firming capabilities.

These designers and department store products can cost between $30 and $130 (or even more) for a one-ounce bottle of serum. Among other products, you'll find these, all of which fall within that price range:

NuFace Smoother (S2) Peptide Serum
Dr. MJ Syn-Ake Venom Lifting Cream
Nutri Syn-Ake Peptide Complex
Why pay so much when you can purchase a bottle of pure Syn-Ake that you can then add to any existing or DIY serum, lotion, or cream? Thus making skincare affordable and costing less than department store brands.

Plus, you get the best results possible for your skin when choosing to enhance your skincare products with products like Syn-Ake from our DIY Collection.

SYN, SYN-AKE, REGU, and REGU-AGE are trademarks of DSM.

Applications:

  • Anti-Aging Facial Serums
  • Body Butters
  • Day and Night Firming Moisturizers
  • Eye Gels and Creams
  • Hyaluronic Face Serums
  • Firming Lotions
  • Smoothing Syn-Ake Sheet Mask with Viper Venom
  • Wrinkle Patches, Eye Patches, and more!

MSDS Sheet

DSM Nutritional Products AG

850061380500

Do not directly apply to your skin. Instead, this product should be added to a formulation at the recommended usage rate.

For external use only, all products are cosmetic grade.

The Food and Drug Administration has not evaluated statements contained herein. This product is not intended to diagnose, treat, cure, or prevent disease. Always consult with your professional skin care provider.

California Prop 65 Statement: The following statement is made to comply with the California Safe Drinking Water and Toxic Enforcement Act of 1986. This product is not known to the State of California to cause cancer, birth defects, or other reproductive harm.

Intro music

Slide 1:
Anti-Aging Solutions
Rejuvenate with Smoothing and Firming Syn®-Ake

Slide 2:
Video of what it is.
Boost any skincare product's effectiveness.
Simply add 45 drops of Syn®-Ake to a 1-ounce base, custom formula, or existing product for a 5% concentration.

Slide 3:
Highest Quality Anti-Aging Peptide for Making Skincare
Syn®-Ake or Dipeptide Diaminobutyroyl Benzylamide Diacetate, an anti-aging peptide that smooths and tightens the skin, targets the forehead, and vertical marionette lines, firming facial features.

Slide 4:
Syn®-Ake Benefits -
Anti-aging
Anti-wrinkle
Smile and frown lines (marionette lines)
Skin tightening
Firms and lifts

Slide 5:
Skin Perfection Logo
Supercharge your skin with the highest quality anti-aging peptides.

Outro music

INGREDIENTS MATTER.

Inspired by wrinkle-smoothing treatments that smooth frown lines, the 11's, and vertical wrinkles. Syn-Ake minimizes the appearance of expression lines and wrinkles, and provides a smoother and more relaxed complexion.
Dipeptide

Customer Reviews

Questions & Answers

Have a Question?

We answer by email, and helpful questions may be added to this page.

QWhy is Syn-Ake so effective?
A
Syn-Ake is made up of peptides that focus on the immediate smoothing and lasting relaxing of the mimic wrinkles, the vertical wrinkles bewtween the brows. They are also called the 11's or frown lines. 

Syn-Ake can also work on smoothing other areas of the face, such as around the mouth and above the upper lip.
Qit's really difficult for me to count out 45 drops. How many pipettes would 45 drops be, roughly?
A

5 drops shy of a half a teaspoon.

QApproximately how many drops are in the bottle? I need to know how far 1 bottle goes. Thank You
A
There are approximately 300 drops in one .5 ounce bottle.
QI purchased the syn-ake and i have been using for over 30 days. I have no tightening at all and the lines on the forehead are the same. I do not see a difference at all
A
Make sure you are using a 5% concentration of Syn-Ake, two times a day. Using it with Pepha Tight (tightener), Syn Coll (collagen boost), Snap-8 (anti-wrinkle peptide) will boost its effectiveness.
QI mixed this peptide with a serum. How long must I wait until I apply an oil to my face and sunscreen?
A
As soon as it is dry, you can apply an oil. Generally, it should only take a few seconds to dry.
QCan I add any of your boosters i.e. Syn-Ake, Matrixyl 3000, Relistase, and Juveleven to a pure aloe Vera base (I have my own plants)? And do you have a recipe I can use? I plan on adding some of your Hyaluronic Acid to this super serum.
A
Yes, you can add any of our Serum Boosters, including, but not limited to, Syn-Ake, Matrixyl 3000, Relistase, and Juveleven Peptide to an Aloe Vera Base. Hyaluronic Acid would also make a great addition. You can find our recipes in the formulary.
QIs this the best peptide for forehead wrinkles?
A
Syn-Ake is great for smoothing forehead wrinkles. It also works on vertical wrinkles including the 11's. We recommend using it with Snap 8, Syn-Coll and Uplevity or another tightener for a complete blend to target forehead wrinkles.
QCan Syn-Ake be used all over the face and neck? Or, is it a target peptide to be used only on certain areas of the face?
A
Syn-Ake can be used in an all-over face and neck serum or used as a spot treatment. It smooths out and relaxes lines

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